聚羟基脂肪酸酯（PHA）的微生物资源、合成过程及包装应用研究进展

宏丹; 刘宏艺; 裴阳阳; 胡雨昊; 陆佳; 杨岳; 王朝晖; 马爱进

doi:10.19554/j.cnki.1001-3563.2026.11.011

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包装工程（技术栏目） ›› 2026, Vol. 47 ›› Issue (11) : 103-115. DOI: 10.19554/j.cnki.1001-3563.2026.11.011

先进材料

聚羟基脂肪酸酯（PHA）的微生物资源、合成过程及包装应用研究进展

宏丹^1,2, 刘宏艺¹, 裴阳阳¹, 胡雨昊¹, 陆佳¹, 杨岳¹, 王朝晖^1*, 马爱进²

作者信息 +

Research Progress on Microbial Resources, Synthesis Process and Packaging Applications of Polyhydroxyalkanoates (PHA)

HONG Dan^1,2, LIU Hongyi¹, PEI Yangyang¹, HU Yuhao¹, LU Jia¹, YANG Yue¹, WANG Zhaohui^1*, MA Aijin²

Author information +

文章历史 +

摘要

目的系统阐述聚羟基脂肪酸酯（PHA）的微生物来源、生物合成途径及代谢调控机制。揭示其对单体组成、分子结构与材料性能的影响,并评估其在食品包装中的应用潜力与挑战。方法梳理PHA的主要微生物资源、生物合成途径及代谢调控机制,重点分析β-氧化途径与脂肪酸合成途径在不同类型PHA形成中的作用,比较代谢调控与碳源策略对材料性能的调节效果,并总结PHA在食品及智能包装中的应用进展。结论不同合成途径与调控策略决定PHA的结构组成及性能特征,通过代谢调控、共聚改性及材料共混可实现对力学性能和功能属性的定向优化,满足食品包装多样化需求。然而,其规模化应用仍受限于生产成本、部分性能不足及功能添加物潜在迁移风险。未来需加强精准合成调控、材料性能设计及迁移行为与法规符合性研究,以推动PHA在食品包装领域的高值化与安全应用。

Abstract

The work aims to systematically summarize the microbial sources, biosynthetic pathways, and metabolic regulatory mechanisms of polyhydroxyalkanoates (PHAs), and to reveal their effects on monomer composition, molecular structure, and material properties and evaluate their application potential and challenges in food packaging. The major microbial resources, biosynthetic pathways, and metabolic regulation strategies of PHA were comprehensively reviewed, with particular emphasis on the roles of the β-oxidation pathway and fatty acid synthesis pathway in the formation of different types of PHAs. The effects of metabolic regulation and carbon source strategies on material properties were comparatively analyzed, and recent advances in PHA applications in conventional and intelligent food packaging were summarized. Different biosynthetic pathways and regulatory strategies play a decisive role in determining the structural composition and performance characteristics of PHAs. Through metabolic regulation, copolymerization modification, and material blending, the mechanical properties and functional attributes of PHAs can be effectively tailored to meet diverse food packaging requirements. However, large-scale application remains constrained by high production costs, suboptimal material properties, and potential migration risks associated with functional additives. Future research should focus on precise biosynthetic regulation, material design optimization, and systematic evaluation of migration behavior and regulatory compliance to promote the high-value and safe application of PHA in food packaging.

导出引用

宏丹, 刘宏艺, 裴阳阳, 胡雨昊, 陆佳, 杨岳, 王朝晖, 马爱进. 聚羟基脂肪酸酯（PHA）的微生物资源、合成过程及包装应用研究进展[J]. 包装工程. 2026, 47(11): 103-115 https://doi.org/10.19554/j.cnki.1001-3563.2026.11.011

HONG Dan, LIU Hongyi, PEI Yangyang, HU Yuhao, LU Jia, YANG Yue, WANG Zhaohui, MA Aijin. Research Progress on Microbial Resources, Synthesis Process and Packaging Applications of Polyhydroxyalkanoates (PHA)[J]. Packaging Engineering. 2026, 47(11): 103-115 https://doi.org/10.19554/j.cnki.1001-3563.2026.11.011

中图分类号： TB484

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