The work aims to put forward the parameterization design system of hydraulic cylinder with respect to the problems of various design standards of hydraulic cylinder and repetitive design of series products of such packaging machinery as packaging machine. With Ansys as the platform, the secondary development of Ansys software was achieved by C++ and APDL through the technologies of hybrid programming and software communication. The parameterization design system that automatically matched the cylinder model based on the working conditions was developed. The data transmission and communication between VC++ and Ansys software were established to automatically complete the modeling and stress analysis of the cylinder in the Ansys environment. After verification, the design results of the system meet the strength requirements. The requirements for the background knowledge of the designer and installation personnel are low. In such case, the system can be used by a vast majority of personnel and it will be a great help to improve the efficiency of design and analysis.