The work aims to study the relationship between the heat sealing quality of EPE packaging bag and heat sealing parameters (electric wire diameter, heat sealing time, heat sealing pressure), and analyze the characteristics of elastic packaging materials heat sealing process. The influence of heat sealing parameters on the heat sealing strength of pearl wool was studied by observing the morphology of micro sealing and comparing the heat sealing strength with different parameters, and its cause was analyzed. In the process of heat sealing the 1.0 mm pearl wool with the 0.8 mm electric wire when the heat sealing was 0.2 MPa and heat sealing time was 2 s, the heat sealing quality was the best and the efficiency was the highest. The compressibility of elastic material causes the influence of sealing pressure on the heat sealing strength to increase significantly with the increase of the electric wire diameter. With the springback characteristics of the elastic material, the electric wire diameter and the heat sealing time have more significantly direct influence on the heat sealing defects.