The work aims to evaluate usability and explosion-proof function of copolymerization reticulated polyurethane explosion-proof material. The explosion-proof mechanism of copolymerization reticulated polyurethane explosion-proof material was introduced. According to the working conditions and explosion-proof assessment requirements of the vehicle's fuel tank, the adaptability test of refueling, vibration and high-temperature storage, as well as the oil patching, 40 mm projectile static blast experiment and other explosion-proof tests with the fuel tanks filled with explosion-proof material were carried out. The result showed that, the materials had good defoaming effect and it could reduce the solid particle contaminants in fuel. Compared to the blank diesel sample, the contents of solid particle contaminants in 0# and -35# diesel were respectively 37.6% and 52% after the high-temperature storage for a long time. The fuel tanks had no explosion both in the shooting test during and after the oil patching and in the 40 mm projectile static blast experiment. The copolymerization reticulated polyurethane explosion-proof material has good compatibility with the fuel and excellent explosion-proof performance.