The work aims to establish an effective flame retardant usage specifications and regulatory system, and determine the content of 5 kinds of organic phosphate flame retardants in soft packaging materials by microwave extraction-GC-MS method. Taking the soft packing material as the research object, the samples were extracted by microwave, separated by the DB-5 chromatographic column, and determined by GC-MS. In the range of 0.2~50.0 mg/kg, the linearly dependent coefficients were greater than 0.9994, and the linear relationship was good; the detection limit was 0.05~0.10 mg/kg and the limit of quantitation was 0.2~0.5 mg/kg; the rate of recovery was 85.6%~104.7% of standard addition, and the relative standard deviation ranged from 1.3%~2.5%. The proposed method is simple and rapid, and it can meet the requirements of the detection of 5 kinds of organic phosphate flame retardants in the soft packaging materials.