The work aims to prepare a fluorine-containing acrylate resin high-lyophobic packaging film. Through a suspension polymerization method, a series of fluorine-containing acrylate resin films having low surface energy were prepared, with methyl methacrylate (MMA), hexafluorobutyl methacrylate (HFMA) or dodecafluoroheptyl methacrylate (DFMA) as a monomer, dibenzoyl peroxide (BPO) as an initiator and sodium dodecyl benzene sulfonate (SDBS) as a dispersant at (78±2)℃ and a rotation speed of 300 r/min. The relevant tests and discussions were carried out through infrared spectroscopy (IR), SEM contact angle and thermal gravity analysis (TG), etc. With HFMA/MMA system as a monomer, when the initiator BPO was 1% of the total reactant mass and the mass ratio of HFMA/MMA was 1∶1, the contact angle of the liquid on the synthetic fluorine-containing acrylate resin film was the largest, and the distilled water had a contact angle of 164.3°. The synthetic fluorine-containing acrylate resin film sample has high-lyophobic property and can be used to prepare inner packaging films of hydrophobic and milk-repellent products.