The work aims to study and develop an automatic printing system for micro bottle marks, which can automatically print the micro conical and cylindrical bottle marks used for the packaging of the pills with diameters from 4 mm to 8 mm. Based on the analysis of the micro bottle’s appearance and the printing condition of its marks, a comparison between the screening and process of printing methods was made to determine the overall design scheme and basic composition of the system. The key technical problems of the feeding vibration plate, finishing mechanism, transmission mechanism, receiving mechanism and printing mechanism found in designing the system were studied and solved. The pneumatic system and PLC control system were also designed. The actual usage shows that the system is in good working condition and runs efficiently and reliably.