The paper aims to establish a color harmony system with Matlab programming to automatically provide match colors consistent with the Munsell color harmony theory, in order to represent and design color accurately. Strategies on color design in the field of packaging were discussed to emphatically study related key techniques and implementation methods of the systems. The color design process was modeled to establish a color harmony system to provide colors consistent with Munsell color harmony theory by Matlab programming. Based on requirements of users, the system can provide color matching programs with four hue precisions (10-hue, 12-hue, 16-hue and 24-hue) and seven harmony modes (vertical, inner face, circular, inclined inner face of the same color, complementary inclined inner face, inclined cross inner face, spiral). This made color design meet the expectations of people for color design. This system provides users with intelligent color design reference, helps users complete color design quickly, and of great value to use.