To design a new on-line quality call and mutual control system in multistation to prevent a quantity of defective products and a great loss of manpower and material resources caused by that operators of packaging units and case sealing units could not communicate with each other and remind to stop the equipment in time when they found defective products. This system realized real-time information interoperability between the operators of packaging units and case sealing units though controlling carton elevator, carton transportation system, vertical packing machine system and establishing man-machine interactive platform and quality alarm system in every station. The system achieved good economy benefit after being implemented in the cigarette factory. Defective product of packaging units was decreased by 35 percent on year-on-year basis and equipment effective operation efficiency was increased by 0.5%. This technology can be applied to packaging equipment and case sealing equipment of tobacco industry.