To study integration methods and rules of paper-based microfluidic detection chips and the paper packaging of food and medicine. The paper-based microfluidic chips of typical biochemistry features were integrated by printing on the inner side of the packaging with a commercial wax printer. And the application rules of microfluid in paper-based microfluidic chips composed on the inner packing surface were explored. The wax praying printing integrated the paper-based microfluidic chips on the inner surface of traditional food and medicine packaging successfully. Basic chemical/biological test and application such as pH test of liquid could be completed by test. The integration of paper-based microfluidics and paper packaging of food/medicine provide a novel approach for the real time and in-situ self inspection of food quality or drug efficacy. It is featured with low cost, easy operation and high test precision.