The work aims to propose an adaptive rectification control system based on image processing and fuzzy PID control, in order to solve the problem of flexible material deviation in the process of package printing. The working principle of this rectification system was introduced and the packaging material edge was detected by the sensor. The deviation value was obtained by image processing and analysis. Then, the corresponding driving signals were generated based on the rectification algorithm to control the rectification mechanism. An image processing algorithm, including image preprocessing and edge recognition, was put forward for edge recognition of packaging material. Meanwhile, a rectification control system was designed based on the fuzzy PID principle. The adaptive adjustment of PID parameters was realized on the basis of fuzzy rules. Finally, the rectification control system was set up and the related experiments were carried out. System deviations could be controlled within 1 mm with high control accuracy and more ideal steady-state performance. The rectification system designed can meet the requirements of operation accuracy on flexible materials mainly used in package printing.