The work aims to study the evaluation model for damping property of multi-precision instrument packages. Taking the damping system of multi-precision instruments as an example, the damage mechanism of resonance damage and shock damage during highway transportation of multi-precision instruments was studied, to obtain the damping efficiency under resonance damage and the shock damage probability under shock damage of the goods. Then, the weight of each precision instrument in the cargo system was established by combining the brittleness of each precision instrument. Finally, the resonance damage and the shock damage probability were multiplied (from vector points) by the weight of the instrument, and the results of comprehensive evaluation of damping effects of each instrument under resonance damage and shock damage were obtained. The results showed that the damping effect under the synthetic action of four kinds of excitation of precision instrument 1 of example-based cargo system was the best (0.39), while the damping effect of precision instrument 1 in shock damage was the worst (0.21). The anti-resonance performance of precision instrument 1 is very good, but the shock resistance is very poor, which needs to improve and optimize the performance parameters of its damping system.