The work aims to study the influence of the curing technology on the partition coefficient of bisphenol A in the coating of food can. On the basis of single factor experiments, the response surface method was used to analyze the optimization of the curing technology parameter to achieve the maximum partition coefficient of bisphenol A. The primary and secondary sequence of three factors regarding their influence on the partition coefficient of bisphenol A in the migrant content: coating quantity＞curing temperature＞curing time, in which the influence of curing temperature and coating quantity on the migration of bisphenol A was quite significant (P<0.0001), and the interaction between curing temperature and curing time, and the interaction between coating quantity and curing time were quite significant (P < 0.0001). Under such conditions as curing temperature of 200 ℃, coating quantity of 12 g/m2 and curing time of 12 min, the partition coefficient for migration of bisphenol A was the maximum (5993.02). The partition coefficients and experiment value obtained under the optimal technological condition are quite close, which indicates that the technological parameters obtained for such response surface are accurate and reliable and ensure the safety of BPA food can.