The work aims to design a control system in combination with industrial personal computer, motion control card and PLC, with bag packaging production line as research object, so as to improve the automation degree of packaging production line. The main structure of bag packaging production line included many devices, such as sealing segmentation, inkjet printing, bag-putting, quantitative dumping and so on. With industrial personal computer as the core, the corresponding control system was built, and the drivers and sensors in the production line were integrated, so that it had the functions like data processing, signal monitoring and trajectory planning. The software design method was also given. Finally, the system equilibrium problem was discussed based on genetic algorithm and the test verification was carried out. The packaging production line based on the described control system was of high reliability and its qualification rate was 99.9%. It is concluded that the control system of such packaging production line can meet the demand of automatic production.