It aims to explore the application of the five senses design in tourism product and service innovation under the background of experience tourism. This paper introduces the concept of experiential tourism, five senses and the of five senses design. As "Nanhai Tourist Special Train(NTST)" as an example, it elaborates the ideas and methods of five senses design, including VIS and APP design, Cantonese voice service system design, Nanhai special food service design, interactive experience design of Nanhai intangible cultural heritage, and so on. The design of immersive experience tourism based on five sense, is to combine the strong regional culture and entertainment atmosphere, through all kinds of tangible or intangible, online or offline products and services, provide divers and deep experience of five sense for tourists, and try to get through the five sense, let it be done to support each other and repeated stimulation in the whole service process.