The work aims to propose an innovative design method based on QFD and TRIZ in order to research and develop the new type of multi-species mixed packaging machine efficiently and rapidly. In this paper, TRIZ and QFD and other innovative methods were used to design and develop a multi-species mixed packaging machine with respect to the problem of entrepreneurs having a small number of staff and heavy workload, etc. at their early stage of starting online shops and so on. The automatically drawn, formed, closed and sealed carton box can be achieved by such packaging machine in accordance with the packaging varieties required by the operator. Manual delivery of goods was not required in the area of goods delivery. Such packaging machine was personalized packaging machinery for varieties of mixed food. The results show that the innovative design method based on QFD and TRIZ is an effective way. The designed packaging machine can significantly improve the production efficiency of carton packaging and reduce the labor intensity of production, and obtain higher quality of product packaging.