The work aims to design a pneumatic interlock book packaging device, to realize the function of automatic book packaging. Through analyzing the current situation of book packaging, the technological process of opening and packaging actions of the pneumatic interlock book packaging device was studied. A packaging device suitable for book packaging was designed. With the help of Matlab, a mathematical model for kinematic mechanics was established and the simulation thereof was conducted with ADAMS. Finally, the actual test was carried out. The packaging speed of the packaging machine was about 22 books per min. The success rate for packaging remained around 96%, and the breakage rate remained below 3%. The packaging quality was good. The bag opening action of the pneumatic interlock book packaging device is stable and efficient, which realizes the function of automatic book packaging.