The work aims to establish the evaluation method and model of printing mottle based on wavelet detail energy regarding the evaluation and measurement of printing mottle. Taking the printing mottle of copperplate paper for example, the sum of detail energy of denoised image wavelet was used as the evaluation indicator of printing mottle and the correlation analysis was made with the human visual system. Then the evaluation results of the both were compared. The established mottle model of wavelet detail energy was more accurate than the traditional COV model. The correlation coefficient of the traditional model was 0.2009. The minimum correlation coefficient was 0.5256 and it was significantly improved after wavelet detail energy treatment. Taken together, wavelet detail energy model can be used as an effective method for the evaluation and analysis of printing mottle instead of human vision.