The work aims to study the automatic control system of capsule printing machine and the printing scheme of human-machine interface (HMI), so as to achieve the design of capsule automatic printing control system and complete the automatic industrial process of capsule printing and detection. Starting with the industrial process control objects for the capsule printing, and based on PLC and touch screen technology, an overall scheme design of capsule printing control system for capsule printing machine was made to control the process of capsule printing industry and count the results. The control system was easy to operate with good reliability, which greatly improved the production efficiency and product percent of pass. Through test, the maximum production efficiency could reach 70 000 pcs/h and the percent of pass was over 99.95%. The capsule printing system designed can achieve control over the industrial process of capsule feeding, printing, waste detection and elimination, count and discharge. The industrial process can be manually and automatically controlled by operating the touch screen and the functions, such as setting, zero clearing and alarm of count limits of production number, packaging number, and the number of qualified products and rejects are provided.