The work aims to improve the automation of packaging production line. Based on S7-200 PLC and vinylon TK6050ip touch screen, an automatic pneumatic manipulator control system for packaging handling was designed. The hardware structure of control system was designed, and the software programming was done based on the hardware structure. Finally, tests and application researches were carried out. The experimental data showed that this control system could ensure smoothness, accuracy and rapidity, and had such advantages as convenient operation, high efficiency and reliable running. The pneumatic manipulator based on PLC and touch screen control can improve the automation degree of packaging production line, which can meet the requirements of packaging control and production.