The work aims to obtain durability regularity of printed matter. Under certain temperature and illumination conditions, the data regarding storage time and color change of sample sheet and ink were obtained with yellowing resistance tester. Moreover, the regularity of sample resistance to yellowing was obtained in quadratic polynomial fitting method. The study found that the brightness of the sample sheet did not change with the change in anti-yellowing time, and the brightness of the ink sample showed an increasing trend with the anti-yellowing time prolonged. At the same time, the chromatic value b of the sample sheet, ink and printing sample had an increasing trend, which conformed to the changing rule of quadratic function. This study provides a complete research method for the analysis on the durability of printing and packaging products, and theoretical basis for the rational selection of the printing material.