The work aims to propose an artwork anti-counterfeit system based on RFID through analysis on mainstream art anti-counterfeiting technology and combined with RFID technology, so as to design an effective artwork anti-counterfeit system. AES algorithm was used to encrypt data on the label to ensure the security of label data. Hash algorithm was adopted to assist in completing the validation of label data. By relying on the anti-counterfeit features of the labels, the forged labels could not be achieved. The anti-counterfeit of label data could be achieved through the consistency of the label data validated under the assistance by Hash algorithm and the data recorded on the cloud platform. The physical anti-counterfeit of labels could be achieved through the anti-counterfeiting algorithm data fed back by cloud platform upon the validation on labels. By means of analysis and test, the artwork anti-counterfeit system could effectively achieve artwork ant-counterfeit within 1 s. Compared to the traditional anti-counterfeiting way, the anti-counterfeit system combined with Internet of things and computer communication technology can provide more efficient, reliable and convenient anti-counterfeit certification.