The work aims to carry out an in-depth analysis on the factors that affect the adhesion of the water-based gravure ink on polyethylene (PE) film with multiple regression analysis and professional statistical analysis software SPSS. With the quantities added of acrylic resin solution, alcohol, wetting agent and coupling agent, and the pigment/binder ratio as independent variable indicators while the adhesion quality of water-based gravure ink as dependent variable, a mathematical model was built, sample variable values were designed and its adhesion on PE film was tested. Then the regression equation model was obtained with adhesion strength as the dependent variable through the statistical analysis on the sample data carried out with SPSS. The mode’s distinctiveness and validity were tested. A simple program was made with the model as the algorithm, which allowed the model to become a direct and easy-to-use window application. The users only had to enter relevant parameters to predict the adhesion strength of a certain formula. The quantity added of acrylic resin solution and pigment/binder ratio had a negative correlation with the adhesion strength, while the quantity added of alcohol, wetting agent and coupling agent had a positive correlation with the adhesion strength. Acrylic resin solution had a relatively great influence on the adhesion strength, followed by pigment/binder ratio and then the quantity added of alcohol; however, the coupling agent had little influence on it. The model obtained through regression analysis method for the factors that affect the adhesion of water-based gravure ink can better predict the adhesion strength.