The work aims to realize such key techniques as electronic CAM and three-axis synchronous control, etc. with respect to the motion control of pillow packaging machines. Taking the three-servo pillow packaging machine as an example, its specific structure was introduced, including mechanisms such as film-feeding, material-feeding, horizontal sealing, vertical sealing and pocket making former. The movement characteristics of pillow packaging machines were analyzed and its functions were described at the same time. A control system of pillow packaging machine was designed, and the structure of general motion controller was discussed in detail based on DSP. Finally, the software design methods were given. The electronic CAM was realized on the basis of cubic polynomial, given-step and look-up table methods. The three-axis synchronous control of pillow packaging machine was realized by using master-slave synchronous control. The control system could satisfy the requirements of pillow packaging machine for motion control and improve the packaging quality, precision and efficiency with defective rate reduced. The feasibility and effectiveness of the control methods and the system described above are verified by experiments.