The work aims to apply the finite element analysis technology to anti-compressive and anti-vibration properties analysis and optimization design of LCD TV package. With the application of ANSYS Workbench analysis software, the finite element model of LCD TV, cushion and corrugated boxes was built. The situation where packages were subject to deformation and stress as well as the vibration during the transportation was simulated in the process of logistics transportation and warehouse stacking. Multi-objective optimization design of the LCD TV cushioning pad was done with packaging mass, natural frequency and maximum deformation as objective functions. After the static pressure analysis, the maximum deformation of the LCD TV cushion was 0.362 mm, and the maximum stress of the package was 70 339 Pa. After the modal analysis, the first-order natural frequency of the package was 7.7471 Hz. After optimization analysis, the optimal design points of cushion height and top groove depth were 200.83 mm and 19.34 mm respectively. Compared with the original design value, all the performances of the package were improved significantly. Through the simulation analysis and optimization design of LCD TV, the size of the cushion structure can be improved, which saves materials while reducing the damage rate of the product.