The work aims to develop a conveniently-activated time-temperature indicator with solid-state enzyme with glucoamylase and starch as the main raw materials. Glucoamylase microcapsules were prepared and the effects of different factors on the color difference of the indicator were studied based on the reaction system of glucoamylase. The formula of the indicator at 4 ℃ and within 5-6 days was determined. The formula of TTI with solid-state enzyme was determined，and 7 groups of TTI system activation energies were obtained through measuring the reaction rate at different temperatures. The activation energy values were respectively 106.68, 98.47, 87.66, 89.73, 106.74, 97.51 and 87.99 kJ/mol. 7 groups of TTI formulas are obtained at 4 ℃. According to the different activation energies, they can be used to indicate the shelf life of different products.