The work aims to study the effects of monomers on UV-LED curing varnish performance and provide a theoretical basis for correctly selecting UV-LED curing varnish with good printing adaptability. Through controlling the kinds and unchanged proportion of prepolymer, photoinitiators and promoter and then adding the same amount of monomers of different types, the varnish samples were prepared. The viscosity, surface tension, curing rate of varnish and the adhesion and flexibility of varnish curing film were tested. Different monomers had different effects on performances of UV-LED curing varnish. UV-LED curing varnish showed the better comprehensive performance when the ratio of compound monomers was TMPTA: HDDA=3∶7, which conformed to the requirements of the market for varnish. Monomers have a great influence on the viscosity and curing rate of UV-LED curing varnish, and also have a significant influence on the adhesion and flexibility of the varnish curing film.