The work aims to study the mechanized combination measurement of multiple packages and ensure that the total mass conforms to the requirements of measurement accuracy. Based on the theoretical knowledge of the packaging measurement, the combination weighing methods were applied to the combination weighing of the packages, and the structural assumption for weighing equipment was proposed. In addition, the process of the main program’s control system was designed. According to the mathematical knowledge integrated with variance and probability, etc., the accuracy of a combination and the number of weighing hoppers were theoretically analyzed. Finally, the case study was used to compare the accuracy of weighing between artificial combination and computer combination. The device designed for combination weighing could structurally serve the purpose of protecting single biscuit package, and could theoretically meet the requirements of measurement accuracy of some biscuit companies. Its speed and accuracy were higher than those of the artificial combination weighing. Through the research, a mechanical device can be designed to substitute the artificial combination, and the total mass of the combination can meet the requirements of measurement accuracy.