The work aims to improve the adhesion of white UV ink on laser paper with regard to cigarette package and optimize the printing process with the experimental design method for response surface. By taking Double Happiness cigarette label produced with Manroland printing machine as an example, and with the power of UV lamp and the speed of printing machine as the independent variables, and the adhesion of white ink on the laser paper as the dependent variable, the Design Expert software was used to design response surface chart. Multiplex fitting of the two independent variables was conducted to establish the corresponding 3D curve surface and obtain the optimal mathematical model, so as to finally obtain the optimal printing process and have such process verified through experiment. When the power of UV lamp was 120 w/cm, the speed of printing machine was 8,580 sheets/h, the optimal adhesion of white ink on laser paper could be obtained. The experimental design method for response surface used to optimize the printing process of cigarette packages can properly predict the adhesion of white ink on the laser paper at the time of reducing the number of experiments.