The work aims to save the time of design and manufacturing of foam packing, reduce the waste of materials, so as to improve its usability. The models of three kinds of foam packing cases with better sales were established in UG, and then structure static analysis was carried out with the models imported into ABAQUS. Finally, the optimal design of packing case and structure static analysis were conducted according to analysis results. The stress distribution contour of three kinds of sample models and optimized models were obtained. The maximum stress of all three kinds of sample models was applied on the contact area of case cover and the case. The central area of the case cover was subject to maximum deformation. The maximum stress of the optimally designed models decreases and the stress distribution is more rational.