The work aims to obtain optimal structure parameters of plastic perforated board made from PVC, PP and PE based on multiobjective optimization solution of perforated unit of plastic perforated board made from the three materials. Simulation analysis and multiobjective optimization iterative solution were carried out via Ansys Workbench. Optimum structure parameters of hard PVC material were: honeycomb length as 10.135 mm, cell wall thickness as 0.151 44 mm and honeycomb height as 10.925 mm. For PP material: honeycomb length as 10.001 mm, cell wall thickness as 0.150 24 mm, and honeycomb height as 10.621 mm. For HDPE material: honeycomb length as 10.998 mm, cell wall thickness as 0.150 16 mm and honeycomb height as 10.196 mm. The mass of optimized plastic perforated board decreased significantly, that of PVC honeycomb board decreased by 10.74%, PP perforated board by 11.11% and HDPE perforated board by 11.97%. Ansys Workbench-based simulation analysis and multi-objective optimization design is a fast and efficient method to obtain the optimum structure parameters of structural parts.