The work aims to establish the cushioning material performance database to provide data support for cushioning packaging design and obtain scientific cushioning packaging design plan. EPE cushioning performance was tested according to GB/T 8167—2008 Dynamic Compression Test Method of Cushioning Materials for Packaging and the characteristics of vibration transmission of EPE were tested according to GB/T 8169—2008 Test Method for Vibration Transmission Characteristics of Cushioning Materials for Packaging. The maximum acceleration-static stress curve and vibration transmission rate-frequency characteristic curve of EPE were obtained. The design process of EPE cushioning packaging was established, and the software of EPE cushioning packaging design was worked out. The feasibility of the software is verified with examples, with which the design efficiency and quality are improved and a basis is provided for cushioning packaging design of EPE materials.