The work aims to systematically calculate the relationship between coating thickness and such influencing factors as the clearance between two rollers, speed for coating rolls, and fluid consistency and flow index of adhesive. Based on the analysis on the complicated flow mechanism, the 2D numerical simulation for the process of coating the clearance between two rollers with adhesive characterized by non-Newtonian fluid through CFD software was carried out. In the five-roller solvent-free coating project, the coating thickness finally increased notably with the increase in the clearance between two rollers. The coating thickness would decrease with the increase in the speed at which the roller was coated. With the continually increased fluid consistency of the adhesive, the thickness of the coating ultimately transmitted to the substrate would decrease. The clearance between two rollers has the largest effect on the coating thickness, and the fluid consistency and flow index of the adhesive also have a big impact on the coating thickness.