The work aims to study the purchasing management and stock management of the small and medium-sized printing corporations based on cloud computing, so as to achieve the services of pay-on-demand supply logistics management. First, the business processes based on BPMN (Business Process Model and Notation) and user case were used to analyze the system, and the business processes and data flow models of the system were built. Secondly, the class diagrams were used to design the database of the system, and the service interfaces of system were defined by the standardized service semantic. Finally, the system was developed and tested on the local computer, and the system was deployed on GAE (Google App Engine) platform. The system of small and medium-sized printing corporation supply logistics management based on cloud computing could meet the information needs of the small and medium-sized printing companies, and the pay-on-demand system was easily used and at a low cost. The system combined with the supply logistics management system and cloud computing technology has improved the level of information for small and medium-sized printing companies and reduced the cost of enterprise informatization.