The work aims to study the residual and migration behaviors of printing ink solvent in flexible packaging materials for food and provide a reference of safety risk control to food package manufacturers. Migration and residue behaviors of ink solvent in aqueous food simulation (distilled water), acidic food simulation liquid acetic acid (3%), alcohol (10% alcohol) and fatty food were studied with benzene solvent toluene, butyl acetate ester solvent and butyl ketone solvents of higher detection rate as migration research objects and with PE, PP, PET/CPP, PET/PE, OPP/CPP, PET/PA/CPP as packaging materials. Studies showed that more flexible packaging materials for food had the residue of benzene, ester and ketone volatiles after printing. In simulation of liquid food migration, general migration amount of n-hexane was >10% ethanol > 3% acetic acid > distilled water. The different packing materials also had different migration amount. In conclusion, ink solvent residues and migration behaviors in the food flexible packaging materials primarily are related to the ambient temperature, food properties, and performance-related packaging materials.