The work aims to study the performance of the cam-slider separation device of packing machinery, and use electromechanical co-simulation method to predict the performance of the servo driven cam-slider separation device system. A electromechanical co-simulation analysis method of independent servo driven cam-slider separation device was presented. A dynamic model of the separation device was established and its dynamic characteristics were analyzed. Via analyzing the control system, the three-loop control model was established and parameters were set up. The electromechanical co-simulation model based on ADAMS/Matlab was built up. The simulation results showed that the maximum tracking error reached 4.1709° because of the system load fluctuation. According to the analysis of results, the control system was improved, and the maximum position tracking error was reduced to 0.0440°. The experimental results showed that the system steady-state error was within the allowable range, and the results were basically consistent with the simulation results. In conclusion, using electromechanical co-simulation method can effectively predict the performance of the servo driven cam-slider separation device system.