In the printing industry, synchronous drive control of electronic shaft has been developed continuously. This work aims to study its motor synchronization control strategy and further improve production efficiency and product quality. The existing synchronization control ways were compared. Modeling and simulation were conducted for these several different structures by Matlab. The simulation analysis showed that the existing synchronization control ways had no ideal anti-disturbance performance and synchronous coordination ability. However, relative coupling synchronization control had big overshoot and was mainly applied to the synchronization of two motors. Therefore, an adjacent coupling error control strategy combined with virtual spindle motor synchronous control method was proposed. According to the analysis of its simulation data, the stable time and overshoot it got were both smaller than those of the existing ways and its anti-disturbance performance was also improved. In conclusion, this proposal can improve the synchronous tracking performance and anti-interference ability of the motor synchronization control system and enhance the motor electronic shaft synchronous coordination control ability.