The work aims to conduct contrastive analysis of the edgewise compressive strength of the typical heavy sandwich fiberboard and provide a basis for its reasonable application. Numerical models with big size specification for honeycomb fiberboard and AAB heavy corrugated fiberboard were respectively established by finite element software Ansys. Compressive strength of heavy corrugated fiberboard in longitudinal direction and that of honeycomb fiberboard in two side directions were studied based on buckling criteria. The compressive strength of honeycomb fiberboard in two side directions was higher than that of the AAB heavy corrugated fiberboard on the condition that material, consumption and sample size and shape were all the same. In conclusion, simulated analysis has strict control on material selection, material consumption and size specification of the both two fiberboards and has eliminated the effect of variation at material, consumption, sample size specification, processing technic and environmental conditions on the results of the analysis.