In order to promote the speed and precision of packaging process, the synchronous control performance of packaging machinery should be improved firstly. In this paper, the speed synchronization control of three-servo automatic pillow packing machine was considered as the research object and its working process was analyzed. Considering the imprecision of master-slave synchronization control method, a three-axis synchronous control method for packaging machinery was put forward based on adjacent cross coupling control algorithm. The basic principle of three-axis synchronous control was discussed in detail. Meanwhile, the specific control model was also given. The control method did not only consider the tracking error of each axis itself, but also considered the synchronization error between the two adjacent axes. It could make up the deficiency of the master-slave control mode. Simulation and experimental results showed that the proposed control strategy had high synchronicity, good stability and fast convergence speed.