Current requirements for high-volume liquid filling were advanced to develop the automatic filling technology. In accordance to the requirements, an HFGZ22-Type rotary vacuum filling machine was designed. Comparing all kinds of filling methods, the way of simultaneous vacuum pumping and filling was adopted, and the filling volume was controlled by using the principle of air pressure balance. According to the characteristics of the target liquid, bottles were held up by mechanical support, and automatically sealed. The application of this machine showed that this machine was characterized by excellent comprehensive properties, high reliability and flexibility, steady performance, and was free of liquid leakage, and thus the desired design goals were achieved. This type of filling machine could be widely used in food and beverage production enterprises.