To solve the problem of formaldehyde releasing from laminate flooring, the hot-pressing technology of equilibrium paper with soy protein-based adhesive for laminate flooring was studied. The protein-based adhesive could be used to press equilibrium paper and laminate flooring. The hot-pressing technology of equilibrium paper with soy protein-based adhesive for laminate flooring was optimized by using response surface method. It was found that soy protein-based adhesive could be used to press equilibrium paper in hot-pressing technology. The parameters used for the hot-pressing temperature, hot-pressing pressure, hot-pressing time and adhesive dosage were controlled at 133.6 ℃, 2.6 MPa, 2.3 min, 96.9 g/m2 respectively during hot pressing. Moreover, the surface bond strength reached 1.31 MPa, which met the National Standard: GB/T 18102—2007. In conclusion, soy protein-based adhesive could be used to press equilibrium paper for laminate flooring.