This work aimed to research the factors that affect the shelf life of carbonated soft drink. Taking carbonated soft drink packaged with PET bottles as research object, the paths of carbon dioxide leakage from PET bottles were analyzed, and the effects of main factors such as temperature, bottle wall thickness, carbon dioxide barrier and gas content on the leaking rate were studied through four types of experiments. At normal temperature, the bottle was the major carbon dioxide leakage path. Therefore, the shelf life could be increased by increasing bottle wall thickness, decreasing storage temperature, adding carbon dioxide barrier and enhancing gas content. In contrast, at high temperature, the shelf life of drink with higher gas content might be shorter. In conclusion, the relationship between different storage temperature, bottle wall thickness, initial gas content, addition of carbon dioxide barrier and the product shelf-life was obtained through experiments.