This work aimed to study the migration of BPA from the inner coating of metal food cans. HPLC and GC-MS were used to determine the migration of Bisphenol A in the inner coating of the food cans. For HPLC method, the recovery was 92.6%~102.4%, the linear range was 0.02~50 mg/L, the linear correlation coefficient was 0.9998, the degree of precision was 4.0%, and the detection limit was 0.0012 mg/L. For GC-MS method, the recovery was 84.8%～103.2%, the linear range was 0.05~200 mg/L, the linear correlation coefficient was 0.9944, the degree of precision was 4.5%, and the detection limit was 0.03 mg/L. These two methods were compared with UPLC-DAD and UPLC-MS methods based on the protocols described by the literatures. The HPLC-FD method had the advantage of low detection limit, high precision, small random error, high stability, wide application range, simple sample preparation and low testing cost. Therefore, it was the preferred method for the determination of BPA migration.