The aim of this study was to investigate a comprehensive quality evaluation method of polyvinyl chloride foam leather for hardcover of books. Using the method of combining the micro structural analysis and macro quality test, the correlation between the two was discussed by means of quantitative characterization and statistical distribution calculation of data. The physical properties of two kinds of foam leather and foam structure were compared respectively. The foam leather with uniform pore structure, fine distribution and low perforation had better test results of physical performance. There was a certain relativity between the micro structure and macro properties of foam leather, and the microstructure had a certain influence on the macro performance. The more complete the pore structure of the foam leather, the higher the uniformity of the pore size and distribution, and the better the performance and the resistance to folding.