This work aimed to study the adhesion of alcohol soluble resin to different materials and the properties of the inks using alcohol soluble resin as the main ingredient. A alcohol soluble resin was synthesized with styrene and 2-ethylhexyl acrylate as the hard and soft polymeric monomers, respectively, acrylic acid and N-methylol acrylamide as the functional monomers, and ethanol as the solvent. Black and blue gravure everse inks were prepared using alcohol soluble resin as the main ingredient and the dispersing agent, carbon black and phthalocyanine blue as additives. The adhesion of resin to PE, BOPP and NY film was excellent , and the viscosity of ink increased with increasing amount of resin. When the content of alcohol soluble resin was 50% of the total mass, the pigment was 15%, the dispersing agent was 2% and the solvent was 33%, the properties of the ink including the color strength, fineness, viscosity, adhesion, initial dryness, residual solvent and boil water resistance could all meet the requirements of food packaging.