This experiment aimed to detect and analyze the organic residue of solvent-based gravure ink, so as to provide basis for risk monitoring of solvent-based gravure ink. The standard curves of 12 kinds of organic solvents were established by referring to the QB/T 2929—2008. Taking the BOPP film as substrate, under the conditions of different ink thicknesses and drying time, the detection of residual quantity of 12 kinds of organic solvents was conducted and the relationship of residual quantity with ink layer thickness and drying time was analyzed. The residual quantity increased with increase of ink layer thickness and decreased with the increase of drying time, both in a linear trend. The change of residual quantity of acetone and acetic ester was the most obvious. The research results can provide scientific basis for the control of ink layer thickness and drying time for plastic packaging printing and data basis for the formulation and revision of the risk monitoring standards for food related materials.