This study was aimed to improve the comprehensive competition ability of small and medium-sized packaging enterprise, and meet the personalized needs of customers. A cloud manufacturing service platform was developed for small and medium-sized packaging enterprises using multiple companies, multiple orders, multi-party collaboration, and multi-dimensional service trade. Based on the idea of creative intelligence service, the workflow and core function of the cloud manufacturing service platform were designed. The key problems in the cloud manufacturing service platform such as trading synergy logics and the intelligent matching method of supply and demand were studied, and the semantic intelligent search based on keywords, trading synergy, order tracking and the whole process of collaborative intelligent management were realized. Taking the application in research and development, design, production, sales and logistics process of a packaging product as an example, simulation analysis revealed the order completion efficiency was enhanced by 20.5%, and the overall packaging efficiency, quality and customer satisfaction were improved, proving the feasibility and the necessity of cloud manufacturing services in the packaging industry.