This work was aimed to study the MCDM method of selecting Vertical Form-Fill-Seal (VFFS) packaging machine under uncertainty. The selection problem of VFFS packaging machine was described after analyzing the benefit and the cost criteria of VFFS packaging machine, the uncertain MCDM model was constructed based on the TODIM method, and then the selection of VFFS packaging machine was analyzed and verified. The subjectivity and uncertainty of criteria weights and qualitative criteria were resolved by the intuitionistic fuzzy weighted averaging (IFWA) operator. Taking into account that decision makers have reference dependent and loss avoidance behaviors, the TODIM was used for the selection of VFFS packaging machine. Using IFWA operator and TODIM combination method to solve the fuzzy, uncertain decision information processing and to get the global value of each alternative scheme, it was helpful to select the optimal VFFS packaging machine from different types.