Based on the existing multi-PASS printing mode for the inkjet plate-making technology, this article aimed to improve the image quality and the reliability of the inkjet plate-making technology by redesigning the printing method of each PASS. First, the random-print mechanism was theoretically demonstrated, and then the image effects of the plates outputted respectively in two different methods using the same one-bit-tiff file were comparatively analyzed. The experimental results showed that the random-print mode broke the regularity of every PASS in the transverse direction, inhibited the defects influencing the inkjet plate quality, and significantly improved the image quality in the inkjet plate. In conclusion, the random-print mode effectively improved the image quality in the inkjet plate.