To explore the applicability and accuracy of the Scatchard-Hildebrand thermodynamic model in predicting the partition coefficient of compounds in printing lay of plastic migrant to food, the related literatures were collected, represented by five kinds of migrants in printing layer of Polyamide (PA), the experimental test data of harmful chemicals in printing layer of PA migrant to different food simulations were selected. Then the experimental partition coefficient value Fexp and the predict one Fsim by the model were comparatively analyzed. And the Scatchard-Hildebrand thermodynamic model was corrected with experimental values. The correlations between the correction coefficient Ks (Ks=ln(Fsim/Fexp)) and migration molecular weight(M), migration alcohol/water partition coefficient(log P) and simulation liquid polarity (Ps) were investigated. The results showed that significant linear correlations were found between the correction coefficient Ks of the partition coefficient predictive model of chemicals in printing layer of PA migrant to food simulations and M and Ps. And the corrected Scatchard-Hildebrand thermodynamic model was set up. To some extent, the corrected Scatchard-Hildebrand thermodynamic model could predict the partition coefficient of harmful compounds in printing layer of PA migrant to food simulations.